Anti-idiotypic antibodies function as a surrogate surface epitope of Brugia malayi infective larvae.
Identifieur interne : 00DA67 ( Main/Exploration ); précédent : 00DA66; suivant : 00DA68Anti-idiotypic antibodies function as a surrogate surface epitope of Brugia malayi infective larvae.
Auteurs : C K Carlow [États-Unis] ; P. Busto ; N. Storey ; M. PhilippSource :
- Acta tropica [ 0001-706X ] ; 1990.
Descripteurs français
- KwdFr :
- Animaux, Anticorps anti-idiotypiques, Anticorps antihelminthe (biosynthèse), Antigènes d'helminthe, Antigènes de surface, Brugia (immunologie), Femelle, Filariose lymphatique (), Isotypes des immunoglobulines (biosynthèse), Larve (immunologie), Souris, Souris de lignée BALB C, Vaccins (immunologie), Épitopes.
- MESH :
- biosynthèse : Anticorps antihelminthe, Isotypes des immunoglobulines.
- immunologie : Brugia, Larve, Vaccins.
- Animaux, Anticorps anti-idiotypiques, Antigènes d'helminthe, Antigènes de surface, Femelle, Filariose lymphatique, Souris, Souris de lignée BALB C, Épitopes.
English descriptors
- KwdEn :
- Animals, Antibodies, Anti-Idiotypic, Antibodies, Helminth (biosynthesis), Antigens, Helminth, Antigens, Surface, Brugia (immunology), Elephantiasis, Filarial (prevention & control), Epitopes, Female, Immunoglobulin Isotypes (biosynthesis), Larva (immunology), Mice, Mice, Inbred BALB C, Vaccines (immunology).
- MESH :
- chemical , biosynthesis : Antibodies, Helminth, Immunoglobulin Isotypes.
- chemical , immunology : Vaccines.
- chemical : Antibodies, Anti-Idiotypic, Antigens, Helminth, Antigens, Surface, Epitopes.
- immunology : Brugia, Larva.
- prevention & control : Elephantiasis, Filarial.
- Animals, Female, Mice, Mice, Inbred BALB C.
Abstract
Anti-idiotypic (AB2) antibodies were generated in rabbits following immunization with a murine IgM monoclonal antibody (AB1) recognizing a surface determinant of Brugia malayi infective stage larvae. AB2 specifically inhibited the binding of AB1 to B. malayi larvae. Furthermore, AB2 had the ability to mimic the original antigen since mice immunized with AB2 possessed serum antibodies (AB3) specific for the B. malayi surface determinant. The presence of anti-surface antibodies (AB3 and AB1) induced either by AB2 immunization or by administration of AB1, did not alter the outcome of an intraperitoneal infection of B. malayi larvae in BABL/c mice when compared to untreated animals. AB3 antibodies like AB1, were IgM, thus indicating an isotype restricted response to the B. malayi epitope. There were no detectable cell mediated responses to the surface determinant in mice immunized with AB2, assessed by lymphocyte blastogenesis or IL3 production in vitro in response to the idiotope as presented by living larvae. The lack of cellular responses and/or the previously demonstrated rapid shedding of the epitope may explain the inability of AB1 or AB2 to protect mice against larval challenge in this study.
PubMed: 1700584
Affiliations:
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Busto</name></author><author><name sortKey="Storey, N" sort="Storey, N" uniqKey="Storey N" first="N" last="Storey">N. Storey</name></author><author><name sortKey="Philipp, M" sort="Philipp, M" uniqKey="Philipp M" first="M" last="Philipp">M. Philipp</name></author></analytic><series><title level="j">Acta tropica</title><idno type="ISSN">0001-706X</idno><imprint><date when="1990" type="published">1990</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Anti-Idiotypic</term><term>Antibodies, Helminth (biosynthesis)</term><term>Antigens, Helminth</term><term>Antigens, Surface</term><term>Brugia (immunology)</term><term>Elephantiasis, Filarial (prevention & control)</term><term>Epitopes</term><term>Female</term><term>Immunoglobulin Isotypes (biosynthesis)</term><term>Larva (immunology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps anti-idiotypiques</term><term>Anticorps antihelminthe (biosynthèse)</term><term>Antigènes d'helminthe</term><term>Antigènes de surface</term><term>Brugia (immunologie)</term><term>Femelle</term><term>Filariose lymphatique ()</term><term>Isotypes des immunoglobulines (biosynthèse)</term><term>Larve (immunologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Vaccins (immunologie)</term><term>Épitopes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Helminth</term><term>Immunoglobulin Isotypes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Vaccines</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antibodies, Anti-Idiotypic</term><term>Antigens, Helminth</term><term>Antigens, Surface</term><term>Epitopes</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Isotypes des immunoglobulines</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Brugia</term><term>Larve</term><term>Vaccins</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia</term><term>Larva</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Mice</term><term>Mice, Inbred BALB C</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Anticorps anti-idiotypiques</term><term>Antigènes d'helminthe</term><term>Antigènes de surface</term><term>Femelle</term><term>Filariose lymphatique</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Épitopes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Anti-idiotypic (AB2) antibodies were generated in rabbits following immunization with a murine IgM monoclonal antibody (AB1) recognizing a surface determinant of Brugia malayi infective stage larvae. AB2 specifically inhibited the binding of AB1 to B. malayi larvae. Furthermore, AB2 had the ability to mimic the original antigen since mice immunized with AB2 possessed serum antibodies (AB3) specific for the B. malayi surface determinant. The presence of anti-surface antibodies (AB3 and AB1) induced either by AB2 immunization or by administration of AB1, did not alter the outcome of an intraperitoneal infection of B. malayi larvae in BABL/c mice when compared to untreated animals. AB3 antibodies like AB1, were IgM, thus indicating an isotype restricted response to the B. malayi epitope. There were no detectable cell mediated responses to the surface determinant in mice immunized with AB2, assessed by lymphocyte blastogenesis or IL3 production in vitro in response to the idiotope as presented by living larvae. The lack of cellular responses and/or the previously demonstrated rapid shedding of the epitope may explain the inability of AB1 or AB2 to protect mice against larval challenge in this study.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><noCountry><name sortKey="Busto, P" sort="Busto, P" uniqKey="Busto P" first="P" last="Busto">P. Busto</name><name sortKey="Philipp, M" sort="Philipp, M" uniqKey="Philipp M" first="M" last="Philipp">M. Philipp</name><name sortKey="Storey, N" sort="Storey, N" uniqKey="Storey N" first="N" last="Storey">N. Storey</name></noCountry><country name="États-Unis"><region name="Massachusetts"><name sortKey="Carlow, C K" sort="Carlow, C K" uniqKey="Carlow C" first="C K" last="Carlow">C K Carlow</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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